The Difference Amplifier and Common-Mode Rejection
The output responds only to the difference
V1 = 1 V is fixed on the inverting side, and V2 goes into the non-inverting side. The differential gain set by the resistor ratio is 2. Slide V2. The output Vout = 2(V2 − V1) responds only to the difference of the two inputs. When V2 equals V1 the output is zero. Set V2 so the output reaches the target of 6 V.
One signal to +, the other to −
The inverting amplifier took only one input, and through the inverting terminal at that. The difference amplifier splits two signals across both inputs: V2 enters the non-inverting (+) side, V1 the inverting (−) side. While the virtual short keeps the two input potentials equal, the + side pulls the potential toward V2 and the − side holds against V1. The result of that tug-of-war appears at the output, and remarkably it responds only to the difference of the two signals.
Whatever comes in common disappears
When the same signal rides on both inputs — say the noise two wires running side by side picked up together — that is the common mode. Since the difference V2 − V1 is zero, the common mode appears nowhere in the output. When the resistors are matched exactly, that is when the ratio of R1 to Rf on the inverting side equals the ratio of R3 to R2 on the non-inverting side, the common part cancels perfectly. So when a weak signal is brought in from afar over two wires, the difference amplifier erases the noise smeared equally on both and amplifies only the difference. This common-mode rejection is the heart of the instrumentation amplifier.
Differential gain and pure subtraction
The output of a matched difference amplifier is Vout = (Rf/R1)(V2 − V1). The leading Rf/R1 is the differential gain, setting how much the difference is amplified. Make all four resistors equal and the gain becomes 1, so Vout = V2 − V1, a subtractor that takes one voltage straight from the other. Where the inverting amplifier flipped the sign and the non-inverting kept it, the difference amplifier merges their two paths — subtracting one input and adding the other — to become the noise-tolerant building block of measurement.
Back to the first screen
As you slid V2, the output grew as 2(V2 − V1) and reached the target of 6 V at V2 = 4 V (V1 = 1). Where V2 equaled V1 the output was zero, so you saw with your own eyes that the output responds only to the difference. This structure, one signal to + and the other to −, erases the noise smeared equally on two wires and amplifies only the difference. This difference amplification, merging the paths of the inverting and non-inverting amplifiers, is the building block of measurement that draws a weak signal in cleanly from afar.